Scientific Research
The following is a list of scientific references proving the connection between mediator release (immune activation / inflammation) and an astounding variety of acute and chronic health conditions.
By removing the elements (reactive foods and other stressors) which cause this response, you’re allowing the body to self regulate and repair.
This is a key piece in any healing process and a cornerstone of our packages and programs.
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GENERAL: The Role of Mediators/Inflammation In Chronic Disease
MRT Lab and Research: https://www.nowleap.com/research/PublicationsResearch/
https://meganpennington.com/inflammation-as-a-key-player-all-diseases/
https://www.harvardmagazine.com/2019/05/inflammation-disease-diet
https://www.nature.com/articles/s41591-019-0675-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492709/
https://www.sciencedaily.com/releases/2012/04/120402162546.htm (https://www.pnas.org/content/109/16/5995)
https://www.hindawi.com/journals/jir/2018/7197931/
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2222.2010.03639.x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579563/
SPECIFIC: The Role Of Mediators/Inflammation In Specific Conditions
Acne https://pubmed.ncbi.nlm.nih.gov/24062871/
ADHD: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00730/full;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591346/;
https://psychology.uiowa.edu/sites/psychology.uiowa.edu/files/groups/nikolas/files/Millichap-and-Yee-2012.pdf (pg 4); https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)62227-1/fulltext
Aging https://www.vivaliti.com/blog/chronic-inflammation-contributes-aging/
Allergies: https://www.jacionline.org/article/S0091-6749(99)70215-0/fulltext
ALS https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202300573R
Alzheimer’s Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC6214864/
Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997866/#
Arthritis https://pubmed.ncbi.nlm.nih.gov/21781798/;
Asthma: https://www.karger.com/Article/Fulltext/97357;
https://www.nature.com/articles/ni.3049;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162380/
Autism : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027314/;
https://www.spectrumnews.org/news/inflammation-may-reshape-brain-regions-tied-to-autism/;
https://www.frontiersin.org/articles/10.3389/fphar.2020.00886/full;
https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00849/full;
https://bibliotecadigital.exactas.uba.ar/greenstone3/exa/collection/paper/document/paper_10447431_v53_n_p69_Depino;
http://savedbytyping.com/wp-content/uploads/sites/14/2015/11/Brain-mast-cells-Eur-J-Pharmacol-July-2015.pdf;
Autoimmune Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584158/
BiPolar Disorder https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054443/
Blood pressure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418473/
Brain fog: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/
Breast cancer: https://www.sciencedirect.com/science/article/pii/S1044579X19301919 (section 4-6)
https://www.mdpi.com/2072-6694/13/15/3918
https://academic.oup.com/mend/article/26/3/360/2614814
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803035/
Bloating: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097950/
Burnout https://www.mdpi.com/2673-5261/4/3/17#
Candida: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163673/
Cancer https://www.nature.com/articles/s41571-020-00459-9/
https://www.nature.com/articles/s41392-021-00658-5
Cardiovascular Disease: https://pubmed.ncbi.nlm.nih.gov/36361701/
Cholesterol: https://www.health.harvard.edu/heart-health/new-insights-about-inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986484
https://pubmed.ncbi.nlm.nih.gov/26561701/
Coronary Artery Disease: (see below) https://bjsm.bmj.com/content/51/15/1111
Constipation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726336/
Congestion/sinusitis: https://pubmed.ncbi.nlm.nih.gov/9444369/
Diarrhea: https://www.sciencedaily.com/releases/2009/12/091230193241.htm;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179131/
Diabetes Type 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074462,
https://bnrc.springeropen.com/articles/10.1186/s42269-018-0016-3
Diabetes Type 2 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523054/;
Diabetes (all types) https://sma.org/inflammation-in-diabetes/;
https://www.nature.com/articles/s41577-019-0213-9
Depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658985/;
https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-200;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542678/?ref=tomecontroldesusalud.com;
https://www.nature.com/articles/d41586-018-05261-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846682/
Dysbiosis: https://www.nature.com/articles/mi201675
Endometriosis https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(18)30143-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836207/
Fatigue: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/
Fertility https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107847/;
https://www.sciencedirect.com/science/article/abs/pii/S1359610104000061;
Fibromyalgia: https://pubmed.ncbi.nlm.nih.gov/29556959/;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356177/;
https://www.sciencedaily.com/releases/2021/07/210701120703.htm
Fibroids
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152895/;
https://www.hindawi.com/journals/sci/2018/1716246/;
https://www.mdpi.com/2073-4409/10/5/982/htm
Galltones https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1344699/full
Gastritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268659/
GI Issues https://academic.oup.com/femspd/article/24/2/161/756965
GERD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867418;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291500/
Graves Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879490/,
https://www.ncbi.nlm.nih.gov/books/NBK448195/
Hashimotos/Thyroiditis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802023
Headaches: https://www.medcentral.com/pain/chronic/immune-system-headache
Hearing loss: https://www.frontiersin.org/articles/10.3389/fphar.2014.00287/full
Hives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019689/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179371/
Hormones (endocrine system) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199304/
Hot flashes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581385/
Infection/Immunity https://www.jacionline.org/article/S0091-6749(20)30420-6/fulltext
Insomnia https://www.mdpi.com/2077-0383/12/5/1793;
https://journals.sagepub.com/doi/full/10.1177/02698811221112932
Insulin resistance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246086/;
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-016-0303-y;
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749271#
https://www.scientificamerican.com/article/inflammatory-clues/
Irritable bowel syndrome: https://gut.bmj.com/content/gutjnl/early/2023/01/18/gutjnl-2020-320633.full.pdf;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097950/
Leukemia https://nyulangone.org/news/inflammation-levels-tied-severity-blood-cancer#
Lung Cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166205/
Menopause https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01998-9
Mental Health (depression, anxiety) https://cgi.edu/news/surprising-impact-inflammation-mental-health/
Migraine: https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-021-01271-1;
https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14224;
https://www.nature.com/articles/s41598-022-06819-y
Multiple Sclerosis: https://pubmed.ncbi.nlm.nih.gov/30563943/
https://www.sciencedirect.com/science/article/pii/S0896627306007161
Nutrient Imbalance https://onlinelibrary.wiley.com/doi/10.1111/all.15972
Osteoporosis: https://pubmed.ncbi.nlm.nih.gov/20485900/
Osteoarthritis: https://journals.sagepub.com/doi/full/10.1177/1759720X12467868
https://pubmed.ncbi.nlm.nih.gov/36695054/
https://www.verywellhealth.com/osteoarthritis-and-inflammation-2552229
Pain: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214073/;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813778/
Parkinson’s Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC4935292/
Postpartum Anxiety/Depression: https://www.frontiersin.org/articles/10.3389/fgwh.2021.758748/full
POTS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914580/
Psoriasis/Eczema: https://pubmed.ncbi.nlm.nih.gov/22356630/;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122139/
Prostate/PSA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562246/;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221555/
Reynaud’s Syndrome: https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/raynaud-s-phenomenon#
Reflux/GERD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867418
Skin disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156947/
Sleep Apnea: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387387/
Sjorgen’s: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762015/;
(also see 5th testimonial https://meganpennington.com/testimonials/)
Spinal Injury: https://pmc.ncbi.nlm.nih.gov/articles/PMC9454769
Stroke: https://pmc.ncbi.nlm.nih.gov/articles/PMC5081118/
Thyroid nodules: https://www.hindawi.com/journals/ije/2020/9827349/